Search for Hydrophilic Marine Fungal Metabolites: a Rational Approach for their Production and Extraction in a Bioactivity Screening Context.
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Date
2011Author
Le Ker, Carine
Petit, Karina-Ethel
Biard, Jean-Francois
Fleurence, Joel
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In the search for bioactive natural products, our lab screens hydrophobic extracts from marine fungal strains. While hydrophilic active substances were recently identified from marine macro-organisms, there was a lack of reported metabolites in the marine fungi area. As such, we decided to develop a general procedure for screening of hydrophobic metabolites. The aim of this study was to compare different processes of fermentation and extraction, using six representative marine fungal strains, in order to define the optimized method for production. The parameters studied were (a) which polar solvent to select, (b) which fermentation method to choose between solid and liquid cultures, (c) which raw material, the mycelium or its medium, to extract and (d) which extraction process to apply. The biochemical analysis and biological evaluations of obtained extracts led to the conclusion that the culture of marine fungi by agar surface fermentation followed by the separate extraction of the my.....
Resource URL
https://www.mdpi.com/1660-3397/9/1/82Journal
Marine DrugsVolume
9Issue
Article 82Page Range
pp.82-97Document Language
enSustainable Development Goals (SDG)
14.aMaturity Level
ConceptSpatial Coverage
Bay of BiscayDOI Original
https://doi.org/10.3390/md9010082Citation
Le Ker, C., Petit, K.-E., Biard, J.-F. and Fleurence, J. (2011) Search for Hydrophilic Marine Fungal Metabolites: a Rational Approach for their Production and Extraction in a Bioactivity Screening Context. Marine Drugs, 9:82, pp.82-97. DOI: https://doi.org/10.3390/md9010082Collections
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